Clinical Spectrum and Biochemical Profile of Chronic Kidney Disease Patients Attending a Tertiary Hospital Setting in India

  • Dr. Richa Mishra Arya Mahila PG College, BHU, Varanasi, Uttar Pradesh, India
  • Chandra Pati Mishra Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh, India
  • Rana Gopal Singh Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh, India
  • Shivendra Singh Institute of Medical Sciences,BHU, Varanasi, Uttar Pradesh, India
  • Prem Nath Tiwari Indian Institute of Technology, BHU, Varanasi, Uttar Pradesh, India
Keywords: Chronic kidney disease, Diabetes, End-stage renal disease, Glomerular filtration rate, Hypertension

Abstract

Background: The health-care burden due to chronic kidney disease (CKD) has increased worldwide in the past decade. It is associated with many features such as hyperkalemia, hypocalcemia, hyponatremia, hypoalbuminemia, and high blood pressure. By early detection and prompt treatment, we can extend the quality of life of CKD patients. Elucidating the biochemical profile of CKD may help in identifying strategies for prevention and management both in the population and at patient level. Purpose: The purpose of this study was to assess the clinical spectrum and biochemical profile of the CKD patients. Materials and Methods: This hospital-based cross-sectional study was conducted at the Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India. All the confirmed incident 175 cases of CKD attending the outpatient department (twice a week) and the Department of Nephrology of Sir Sunderlal Hospital, Banaras Hindu University, Varanasi, Uttar Pradesh, India, were considered as the cases of the study. Sociodemographic profile and clinical spectrum of the study participants were obtained by interviewing them. Their biochemical profile was assessed following standard laboratory procedures. Results: Male-to-female ratio of CKD patients was 2.1:1, and 44.6% of the patients were from urban area. All the 82.3% of the patients were in Stage IV and Stage V. The common clinical manifestations were weakness (90.9%), decreased appetite (82.9%), fatigue (79.4%), bad mouth odor (74.3%), and nausea (61.7%). Burning micturition and decreased urine output were present in 46.9% and 34.3% of the patients, respectively. Weight loss (58.9%) and muscle cramps (53.7%) were other significant manifestations. Hypoalbuminemia, hypocalcemia, hyponatremia, and hypozincemia were present in 38.3%, 60.0%, 33.7%, and 81.7% of the patients, respectively, whereas 40.0% of the patients had hyperphosphatemia. There existed a significant association in the stages of CKD and serum urea, creatinine, uric acid, and phosphorus. Conclusion: Clinical and biochemical profile provided a significant input for the management of CKD.

Author Biographies

Dr. Richa Mishra, Arya Mahila PG College, BHU, Varanasi, Uttar Pradesh, India

Assistant Professor, Department of Home Science

Chandra Pati Mishra, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh, India

Professor, Department of
Community Medicine

Rana Gopal Singh, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh, India

Distinguished Professor, Department of Nephrology

Shivendra Singh, Institute of Medical Sciences,BHU, Varanasi, Uttar Pradesh, India

Associate Professor, Department of Nephrology

Prem Nath Tiwari, Indian Institute of Technology, BHU, Varanasi, Uttar Pradesh, India

Retired Professor

Published
2014-12-31
Section
Table of Contents