Effect Red Guava Juice (Psidium guajava L) on Blood Glucose Levels Fasting Wistar Rats Induced Pre-diabetes Dexamethasone
Background: Pre-diabetes is a condition where blood glucose levels are higher than normal but not high enough to say diabetes, and it can develop into diabetes mellitus type 2, two conditions associated with pre-diabetes are impaired glucose tolerance or fasting blood glucose (FBG) disturbed. The purpose of this study was to determine the effect of red guava juice (Psidium guajava L) which is a source of antioxidants on FBG levels Wistar rat strain. Materials and Methods: This research is true experimental design of randomized pre- and post-test with control group design, in which the experimental group was divided into five groups: Control group negative given only the standard feed and drinking water ad libitum, positive control induced with dexamethasone, and three treatment groups by the addition of red guava juice at a dose of 3.6, 7.2, and 10.8 g/head/day given orally. The study was conducted over a period of 3 weeks. Blood glucose levels were taken during pre-treatment for the control and treatment groups, whereas post-treatment for all three treatment groups only, then the data are collected after it is processed using one-way ANOVA statistical test with a confidence level of 95%. Results: The results of this study are dexamethasone improving FBG levels pre-treatment, and post-FBG levels in the treatment group were given red guava juice all decreased. Conclusion: The conclusion of this study is a red guava juice can lower FBG levels in mice pre-diabetes.