Effect Red Guava Juice (Psidium guajava L) on Blood Glucose Levels Fasting Wistar Rats Induced Pre-diabetes Dexamethasone

  • Jasmani Airlangga University Surabaya, Indonesia
  • Bambang Wirjatdmadi Airlangga University Surabaya, Indonesia
  • Merryana Adriani Airlangga University Surabaya, Indonesia
Keywords: Pre-diabetes, Glucose fasting, Dexamethasone, Red guava juice, Rats


Background: Pre-diabetes is a condition where blood glucose levels are higher than normal but not high enough to say diabetes, and it can develop into diabetes mellitus type 2, two conditions associated with pre-diabetes are impaired glucose tolerance or fasting blood glucose (FBG) disturbed. The purpose of this study was to determine the effect of red guava juice (Psidium guajava L) which is a source of antioxidants on FBG levels Wistar rat strain. Materials and Methods: This research is true experimental design of randomized pre- and post-test with control group design, in which the experimental group was divided into five groups: Control group negative given only the standard feed and drinking water ad libitum, positive control induced with dexamethasone, and three treatment groups by the addition of red guava juice at a dose of 3.6, 7.2, and 10.8 g/head/day given orally. The study was conducted over a period of 3 weeks. Blood glucose levels were taken during pre-treatment for the control and treatment groups, whereas post-treatment for all three treatment groups only, then the data are collected after it is processed using one-way ANOVA statistical test with a confidence level of 95%. Results: The results of this study are dexamethasone improving FBG levels pre-treatment, and post-FBG levels in the treatment group were given red guava juice all decreased. Conclusion: The conclusion of this study is a red guava juice can lower FBG levels in mice pre-diabetes. 

Author Biographies

Jasmani, Airlangga University Surabaya, Indonesia

Student of Master Program of Public Health Science, Faculty of Public Health

Bambang Wirjatdmadi, Airlangga University Surabaya, Indonesia

Doctor of Community
Health Nutrition Department, Faculty of Public Health

Merryana Adriani, Airlangga University Surabaya, Indonesia

Profesor of Community Health Nutrition
Department, Faculty of Public Health

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