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Aim: The aim of the study was to determine the prevalence of different signs of combination syndrome among denture wearers of Jammu population. Materials and Methods: The present study was conducted in the Department of Dentistry at District Hospital, Kathua, Jammu, from May 2016 to October 2016. From a total of 376 patients, 113 patients were selected for the study based on the inclusion criteria. Patients were examined for the extrusion of the mandibular anterior teeth (EA), tuberosity overgrowth (TO), mandibular posterior bone resorption (MPR), bone resorption in maxillary anterior region (MAR), and palatal papillary hyperplasia (PPH). Chisquare test was used to interpret the evaluated data. Results: The majority of the subjects have shown the presence of different signs of combination syndrome with 78.7% of the subjects showing MPR, 66.4% subjects having bone resorption in MAR, 63.7% of the subjects showed EA, and 56.6% showed TO. The least prevalent sign was PPH which was shown to be 15.04%. The results were statistically highly significant. The subjects showing the presence of different signs of combination syndrome 65.3% of males and 34.7% females showed EA, 39.1% males and 60.9% females showed TO, 53.9% males and 46.1% females showed MPR, and 49.3% males and 50.7% females showed MAR. PPH was present in 47.1% males and 52.9% females. The gender differences for the presence of different signs of combination syndrome were found to be statistically significant. Conclusion: The combination syndrome was prevalent in 30.05%. The clinical signs of combination syndrome are quite prevalent with least prevalence for PPH. Appropriate evaluation of patients after giving prostheses should be done to minimize the occurrence combination syndrome.